Use of nanostructured systems for active ingredient delivery has been a topic of great interest in recent years. Currently, nanotechnology is present in a variety of cosmetic products available on the market, especially those intended for human use. Despite the promising application of nanotechnology in veterinary medicine, its benefits are still not well-known by professionals in the field.
Nanotechnology applied to animal dermocosmetics involves the use of nanometer-sized systems (diameter less than 1000 nm), such as nanoparticles, containing active ingredients capable of penetrating the deeper layers of fur and skin, enhancing efficacy. Other advantages associated with the use of nanoparticles for the delivery of dermatological actives include: carrying water-insoluble actives, improving product texture, protection against degradation, and gradual release, preventing skin irritations and reducing the application frequency.
In addition to being present in the newest veterinary cosmetics on the market, nanotechnology is also being used in the formulation of compounded products. Among the various nanoencapsulated actives provided by the industry for compounding, raw materials based on natural actives developed exclusively for veterinary compounding stand out. An example is nanocapsules based on tea tree essential oil, a powerful natural antifungal indicated for the treatment of fungal infections like Malassezia pachydermatis. The reduced size of the nanoparticles allows the active to penetrate the deeper layers of the dermis, increasing treatment efficacy. A case study of a dog with advanced chronic Malassezia infection shows the progression of the condition after weekly application of nanoencapsulated tea tree oil. Other indications for nanoencapsulated actives include deep skin and fur hydration. When applied to the animal, nanoparticles form an occlusive barrier that reduces the evaporation of water molecules present in the skin, increasing hydration. Nanostructured moisturizing formulations have been shown to be effective in improving symptoms of canine atopic dermatitis from the first application.
Dog with advanced Malassezia infection: before and after treatment with spray containing nano tea tree oil.
Letícia Mazzarino – Co-founder of NanoScoping Solutions in Nanotechnology. Holds a degree in Industrial Pharmacy (UPF), specialization in Compounding Pharmacy (Oswaldo Cruz University), Master’s degree in Pharmacy (UFSC), and Ph.D. in Pharmacy (UFSC) and in Polymer Sciences (Université Grenoble Alpes – France).
